The pleiotropic benefits

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Webb1 juni 2013 · This paper serves as a focused and updated discussion of the pleiotropic effects of statins in gastrointestinal disorders. The hydroxy-methyl-glutaryl-CoA reductase inhibitors (statins) are used extensively in the treatment of dyslipidemia, and for the prevention and treatment of coronary artery disease and stroke. They have also … Webb30 juni 2024 · To identify statins’ pleiotropic effects, previous studies have used genetically mimicked statins to assess statins’ metabolomic profile , compared it with that of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors , and compared statin’s lipoprotein signature with that of cholesteryl ester transfer protein (CETP) inhibitors .

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Webb1 nov. 2016 · The discrepancies may have resulted from small numbers of exposed cases, improper case validation or study designs comparing effects in statin users vs. nonusers or adherers vs. non-adherers, which, in the case of the pleiotropic benefits of statins, have been shown to pose challenges concerning bias eradication. Webb9 mars 2024 · In their model, the fitness effects of mutations form a continuum, such that the mutations accumulated in the home environment may provide a range of pleiotropic … do the olympic allow transgenders to compete

Pleiotropic Benefits of Statins in Cardiovascular Diseases

Webb6 jan. 2024 · The notion of whether statin pleiotropy has clinical relevance in terms of cardiovascular risk reduction may benefit from ongoing trials … Webb24 aug. 2024 · Increased levels of adenosine and pro-survival kinases, a reduction in fibrosis and lower levels of inflammatory cytokines (TNF-α, interleukin (IL)-1β, and IL … WebbBalakumar, P., Sambathkumar, R., Mahadevan, N., Muhsinah, A. B., Alsayari, A., Venkateswaramurthy, N., & Dhanaraj, S. A. (2024). Molecular targets of fenofibrate in ... city of tucson bulky trash schedule 2023

Case Study: Reducing Renal Progression With SGLT-2 Inhibitors

Pleiotropic Benefits of DPP-4 Inhibitors Beyond Glycemic Control

Webb28 okt. 2024 · Therefore, the inhibition of DPP-4 may have numerous effects beyond glucose control. In this article, we review the pleiotropic effects of DPP-4 inhibitors beyond glucose control, including their strong beneficial effects on the stress induced accelerated senescence of vascular cells, and the possible clinical implications of these effects. WebbTechniques Cochlear explants have been confronted with gentamicin without or with telmisartan, and/or GW9662, an permanent PPAR-γ antagonist. Benefits Telmisartan protected even HCs versus gentamicin-induced ototoxicity. GW9662 completely clogged this specific protecting result, suggesting rrt had been mediated by simply PPAR-γ … city of tucson brush and bulky pick upWebbPleiotropic effects may be undesirable (such as side effects or toxicity), neutral, or, as is especially the case with HMG-CoA reductase inhibitors (statins), beneficial. Pleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, and … city of tucson buyspeed

"WebbTo dissect the genetic basis of cotton breeding in China, a 16-parent cotton MAGIC population was newly developed in this study. 25 pleiotropic genomic loci were identified by GWASs, providing an explanation for the simultaneous changes between cotton yield and fiber quality. The narrow genetic structure of Chinese cotton cultivars was also … " - The pleiotropic benefits

The pleiotropic benefits

Comparative Analysis of the Preventive Effects of Canagliflozin, a ...

Webb11 apr. 2024 · Conflict of interest Scott M. Damrauer receives research support (to the University of Pennsylvania) from RenalytixAI and personal fees from Caico Ibs, both outside the scope of the present work. SMD is also named as a co-inventor on a government-owned US Patent application related to the use of genetic risk prediction for venous … Webb7 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis March 2024 DOI: …

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Webb29 nov. 2016 · Treatment with alirocumab and evolocumab has been shown to significantly reduce triglyceride-rich lipoproteins, possibly through enhanced clearance … Webbför 2 dagar sedan · An inexpensive, five-step synthesis of the flavonol morin on a 40 g scale is described, a natural product that is used in electroplating processes. Comprehensive analysis of the products obtained in the oxidative cyclization of the chalcone precursor with alkaline tert-butyl hydroperoxide (TBHP) was performed. For the …

WebbThis paper builds on these findings and presents practical guidance for maximising the pleiotropic benefits of this class of medicines in people with T2DM in terms of reducing adverse CVD outcomes. The Improving Diabetes Steering Committee aims to offer evidence-based practical guidance for the use of SGLT2i therapies in people with T2DM …

WebbVanderbilt University Medical Center. Mar 2007 - Jul 20147 years 5 months. Nashville, Tennessee, United States. TaqMan Genotyping, Sequenom MassArray, Sanger Sequencing, Illumina Infinium ... Webb13 dec. 2024 · GLP-1RAs have been shown to have advantageous pleiotropic effects, acting in multiple organ systems, with potential cardiovascular benefits. Large trials are still necessary to confirm the potential efficacy of GLP-1RAs in improving the stroke outcomes specifically [ 95 ].

Webb23 sep. 2010 · The pleiotropic properties of chlorthalidone were not appreciated before. and I think this study, although it's a basic science study, does confirm these special benefits chlorthalidone has beyond ...

Webb12 apr. 2024 · Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have been shown to improve cardiovascular and renal outcomes in patients with established cardiovascular disease, chronic kidney disease (CKD), and heart failure (HF) with reduced or preserved ejection fraction. Clinical benefit has been substantiated in patients with and without … city of tucson cesar chavez holiday 2023Webb7 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis Main. Atherosclerosis is a lipoprotein-driven, inflammatory process underlying heart attack and stroke and is … do the olympics have basketballWebb12 apr. 2024 · Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have been shown to improve cardiovascular and renal outcomes in patients with established cardiovascular … city of tucson cdbgWebbHowever, the overall benefits observed with statins appear to be greater than what might be expected from changes in lipid levels alone, suggesting effects beyond cholesterol lowering. Indeed, recent studies indicate that some of the cholesterol-independent or “pleiotropic” effects of statins involve improving endothelial function ... city of tucson businessWebb30 juni 2015 · Pleiotropy arises when a locus influences multiple traits. Rich GWAS findings of various traits in the past decade reveal many examples of this phenomenon, suggesting the wide existence of pleiotropic effects. What underlies this phenomenon is the biological connection among seemingly unrelated traits/diseases. Characterizing the molecular … do the olympics have soccerWebbWe offer real benefits to our authors, including fast-track processing of papers. Learn more. ... To deepen the understanding of SGLT2 inhibitors, experiments focused on other pleiotropic effects of canagliflozin, such as hepatic functional improvement and renal and cardiovascular protection, will be needed. do the olympics start todayWebb12 mars 2013 · The pleiotropic effects attributed to statins are many. 1,2 They include increases in endothelial nitric oxide formation; flow-mediated vascular dilatation; … city of tucson citation lookup