WebDec 5, 2024 · The area postrema is not covered by the blood brain-barrier because it senses toxins in the blood that the other parts of the brain are protected from. The area postrema … WebSep 27, 2024 · We propose a mechanism independent of the vagus nerve and the spinoparabrachial pathway, by which VC neurons directly sense circulating IL-1ß and activate the PB via perivascular cells in the area postrema (AP) …
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WebIn contrast to the pan PDE4 inhibitor roflumilast, the therapeutic dose of both the PDE4B-specific inhibitor A33 and the PDE4D-specific inhibitor Gebr32a did not trigger emesis-like side effects in rodents. Finally, we report distinct PDE4D isoform expression patterns in human area postrema neurons and human oligodendroglia lineage cells. WebJun 14, 2024 · The functions of area postrema inhibitory neurons are unclear. All three area postrema inhibitory neuron types (and none of the excitatory neurons) are marked in Gad2-ires-Cre mice, and genetic tracing previously revealed their projections to be local and largely confined to the area postrema, with minor projections observed in the adjacent nucleus of … praca ndt holandia
How COVID-19 Affects the Brain Neurology - JAMA
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