Photomutagenicity testing
WebAdministration of the second-generation antihistamine, terfenadine, is sometimes associated with photosensitivity and other skin reactions. To obtain information on its photoreactivity, we used a stepwise experimental approach involving tests for photostability, phototoxicity (PT) (mouse fibroblast cell line [3T3] neutral red uptake [NRU] test) and … WebAug 5, 2016 · The main issues identified were related to the quality and level of details of the renewal assessment reports and the adherence to the new data requirements, in …
Photomutagenicity testing
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WebAt the 2009 International Workshop on Genotoxicity Testing in Basel, an expert group gathered to provide guidance on suitable follow-up tests to describe risk when basic in vivo genotoxicity tests ... WebThe relevance of photomutagenicity testing as a predictor of photocarcinogenicity. MUELLER L, KASPER P. Federal Inst. Drugs Med. Devices, Sect. Mutagenicity Carcinogenicity, Seestr. 10, 13353 Berlin, Germany. Today's lifestyle is associated with frequent and intense exposure to ultraviolet radiation (UVR). ...
WebAug 16, 2011 · In the Ames test, the mutagenicity of azulene was assessed in the presence and absence of UV light by use of the Salmonella strains TA102, TA104, TA2638 and E. coli WP2. Azulene was irradiated before being plated with bacteria (pre-irradiation), or concomitantly with the bacteria either after plating or while in suspension. WebAbstract— The Chinese hamster V79 lung cell in vitro micronucleus assay was adapted to detect and quantify phototoxicity and photogenotoxicity of fluoroquinolones. Using this assay, the quinolones ...
WebDOI: 10.1016/0165-1161(93)90027-W Corpus ID: 40094125; Photomutagenesis test development: I. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in bacterial and yeast assays. WebApr 23, 2024 · Thus, the present work aims to evaluate the photomutagenicity of neuroleptic drug chlorpromazine (CPZ), and its N-demethylated metabolites using COMET assay and …
WebAug 16, 2011 · In the Ames test, the mutagenicity of azulene was assessed in the presence and absence of UV light by use of the Salmonella strains TA102, TA104, TA2638 and E. …
WebJan 1, 1990 · In contrast to the phototoxic and photomutagenic properties of many furocoumarins (psoralens), which are well documented in several test organisms and systems (reviewed by Song and Tapley, 1979), only few reports are known which deal with the photogenotoxicity or photomutagenicity of furoquinolines (Ashwood-Smith et al., … imagination and creativity learning zoneWebThe in vitro mammalian cell micronucleus test (MNvit assay) is a method that uses cultured human or rodent cells. It provides a comprehensive basis for investigating chromosome damaging potential in vitro because both aneugens and clastogens can be detected. The test will be performed with the actin polymerisation inhibitor cytochalasin B (Cyto B). list of endangered chicken breedsWeb@article{osti_5517617, title = {Chemical basis for photomutagenicity in synthetic fuels}, author = {Selby, C P and Calkins, J and Enoch, H G and Wright, C W and Wilson, B W}, abstractNote = {Photomutagens (chemicals that enhance the mutagenicity of near UV-visible radiation) have been detected in a variety of experimental coal- and oil shale … list of endangered species in californiaWebJul 1, 2016 · Pho-tomutagenesis test development: I. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in bacterial and yeast assays. Mutat. Res. 292:241–250 ... J. C. Dean, C. N. Martin, and D. J. Kirkland. 1992. Development of assays for the detection of photomutagenicity of chemicals during exposure to UV light. II. Results of testing three ... imagination and creativity in childhoodWebDetecting ctDNA for liquid biopsy applications is challenging because the molecules bearing the cancer mutations are only a small fraction of the total circulating cfDNA collected in … imagination and creationWebJan 1, 2004 · However, there are still no regulatory requirements for photomutagenicity, except a guideline issued by the Scientific Committee of Cosmetology (SSC) on the testing of sunscreens for their photochemical genotoxicity (Gocke et al., 2000; Loprieno, 1991), on which this work was based. list of endangered species animalsWebFeb 1, 2004 · The bacterial photomutagenicity test system (Photo-Ames) has aided the early detection of potential photocarcinogenic substances (Tarozzi et al., 2003) and has been extensively used for this ... imagination and creativity演讲