WebCobicistat. A CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection. Stiripentol. An antiepileptic agent used in combination with other anticonvulsants to treat seizures associated with Dravet syndrome. Web3.2.8.1 CYP3A. CYP3A is responsible for the metabolism of more drugs than any other P450 enzyme. Examples of CYP3A substrates can be found in Table 3.1. Midazolam is one of the “gold standard” probes for CYP3A activity. We conducted a study evaluating the effect of pregnancy on CYP3A activity utilizing midazolam as the probe drug.
CYP3A4 - Wikipedia
WebDrug Interaction Studies - Study Design, Data Analysis, and Implications for Dosing and Labeling. September 2006. Clinical Pharmacology. Accessed last on 5/19/2009. Ohno Y, Hisaka A, Suzuki H. General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs. WebCommon Pharmacogenomics Package analyzes 15 genes that include 2 genes-related to drug hypersensitivity, 9 genes-related to drug-metabolism, and additional 4 genes-related to drug-metabolism in cancer and immunosuppressant covering more than 150 prescribed drugs. Package Name. ct428cfg#01
Cytochrome P450 3A5 (CYP3A5) and Medicines
WebA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. A macrolide antibiotic used to treat and prevent a variety of bacterial infections. A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. WebCYP3A inducers include the glucocorticoids, rifampin, carbamazepine, phenobarbital, and phenytoin. Among the many significant CYP3A inhibitors are grapefruit juice, … WebNational Center for Biotechnology Information ear pain not infection