Citrinin pathway
WebDec 6, 2014 · To learn more about the citrinin biosynthetic pathway, a ctnG-replacement vector was constructed to disrupt ctnG with the hygromycin resistance gene as the selection marker, then transformed into ... WebTo learn more about the citrinin biosynthetic pathway, a ctnG-replacement vector was constructed to disrupt ctnG with the hygromycin resistance gene as the selection marker, then transformed into M. aurantiacus Li AS3.4384 by a protoplast-PEG method. The citrinin content of three disruptants was reduced to about 50%, meanwhile pigment ...
Citrinin pathway
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Citrinin is a mycotoxin which is often found in food. It is a secondary metabolite produced by fungi that contaminates long-stored food and it causes different toxic effects, like nephrotoxic, hepatotoxic and cytotoxic effects. Citrinin is mainly found in stored grains, but sometimes also in fruits and other plant products. See more Citrinin was one of the many mycotoxins discovered by H. Raistrick and A.C. Hetherington in the 1930s. In 1941 H. Raistrick and G. Smith identified citrinin to have a broad antibacterial activity. After this discovery the … See more Citrinin is a polyketide mycotoxin, which is a secondary metabolite of some fungi species. Its IUPAC name is (3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid and the molecular formula is C13H14O5. Citrinin has a … See more Citrinin is biosynthesized by fungi species of Penicillium, Monascus and Aspergillus. For the production of citrinin, a minimal set of genes is needed. These genes are conserved in most … See more Reddy et al. (1982) described the distribution and metabolism of [ C]Citrinin in pregnant rats. These rats were subcutaneously administered with 35 mg/kg C-labeled citrinin on day 12 of pregnancy. From plasma concentrations it could be concluded … See more The existing information on occurrence of citrinin in food suggests that relatively high citrinin concentrations can be found in stored grains and … See more There are different types of toxicity. The types of toxicity that have been studied for citrinin are acute toxicity, nephrotoxicity, genotoxicity and its carcinogenicity. Acute toxicity See more Various in vitro studies have revealed the involvement of citrinin toxicity in reduced cytokine production, inhibition of RNA and DNA synthesis, … See more WebSep 29, 2011 · CIT is synthesized via the polyketide pathway [20]. It is generally known that three secondary metabolites, pigments, monacolin K, and citrinin, share a biochemical …
WebKey Contribution: Optimal biomarkers for exposure were determined for OTA and CIT in pig serum and urine. The prolonged experiment after the exposure of the pigs to feed naturally contaminated with multiple mycotoxin (DON, ZEN, OTA and CIT) allowed to assess the kinetic pathway of mycotoxin biomarkers in pigs and demonstrated why biomonitoring is … WebJan 1, 2016 · The individual steps of citrinin 1 biosynthesis in Monascus ruber M7 were determined by a combination of targeted gene knockout and heterologous gene …
WebAug 31, 1987 · Despite the similarity in structures between citrinin and ochratoxin, the PKS (CitS) catalyzing of the first enzyme-free intermediate (redoxcitrinin) in the citrinin …
WebYes. Some red yeast rice products contain a contaminant called citrinin, which is toxic and can damage the kidneys. In a 2024 analysis of 37 red yeast rice products, only one had citrinin levels below the maximum …
WebFeb 26, 2024 · When data mining was performed on citrinin targets, the top five functional descriptions were a cell’s response to an organic cyclic compound, the netrin–UNC5B … detached retina symptoms painWebJan 1, 1999 · Biosynthesis of citrinin and synthesis of its biogenetic precursors L. Colombo, C. Gennari, D. Potenza, C. Scolastico, F. Aragozzini, C. Merendi Chemistry 1980 … chummed waterWebJun 1, 2007 · Abstract. The mycotoxin CTN (citrinin), a natural contaminant in foodstuffs and animal feeds, has cytotoxic and genotoxic effects on various mammalian cells. CTN … detached roughly crosswordWebFeb 21, 2024 · Citrinin is a toxic secondary metabolite of Penicillium citrinum and its contamination in many food items has been widely reported. However, research on the citrinin biosynthesis pathway and its regulation mechanism in P. citrinum is rarely reported. In this study, we investigated the effect of different carbon sources on citrinin production … chummer 5aWebAbstract ：Two cDNA subtractive libraries of Monascus were constructed by suppression subtractive hybridization(SSH) andscreened of correlative genes from the citrinin biosynthetic pathway in Monascus species. All clones in the two libraries weresequenced and the results were analyzed by bioinformatic softwares. chummer5a latestWebCitrinin appears to be toxic by multiple pathways including inhibition of nucleic acid synthesis, inhibition of microtubule assembly and tubulin polymerization, alteration of … detached retina surgery recovery chairWebJun 28, 2024 · Citrinin targets the kidney, resulting in teratogenicity, carcinogenicity, and mutagenicity. Therefore, decreasing the content of citrinin is becoming a necessity that should be addressed as soon as possible. This study included a comprehensive transcriptomic analysis to elucidate the citrinin synthesis pathway in M. purpureus. chum mens shoes